Is there a way to disable the 'save changes' prompt that comes up when moving between layouts?

Hmmm I suspect no one is answering, because we are not prompted to save every time we switch layouts. You mean, report layouts while maintaining reports? Are you choosing to 'Maintain All Layouts'? You mean in the report editor, when you press <ESC>J or <ESC>K, or click on a different layout, you are getting a save prompt each time? Something odd about that - I don't get that in any of the many versions I work on. What version of tools are you on? Maybe an updated tools / standard program would help.

I haven't replied because I don't have a solution for it, but I have seen it also at one customer site who uses 5c. However I don't have found the time to solve/do a little investigation.

Han